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James Cranley
My clinical interest lies at the intersect of inherited cardiac conditions and electrophysiology. During my research I have created a cell atlas of the human heart.
Education
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Oxford University
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Eton College
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Wellcome Trust Doctoral Fellowship
Teichmann Lab
Sanger Institute
2024 - 2021
PG Certificate in Medical Education
Institute of Continuing Education
Cambridge University
2019 - 2018
NIHR Academic Clinical Fellowship
East of England deanery
Cambridge
2018 - 2015
Membership of the Royal College of Physicians (London)
Royal College of Physicians
RCP
2016 - 2015
Research Experience
PhD Fellowship
Teichmann Lab
Sanger Institute
2024 - 2021
- Single cell and spatial transcriptomic analysis of the adult and developing human heart
- 50% wet lab genomics (single-cell and spatial transcriptomic)
- 50% bioinformatics (python, Bash, R)
Academic Clinical Fellow pt. 3
Munroe Lab
Queen Mary University of London
2018 - 2018
- Genome-wide associattion study into ECG trait (PR interval) using UK biobank data
Academic Clinical Fellow pt. 2
MacRae Lab
Harvard University
2017 - 2017
- Literature review and introduction to zebrafish model
Academic Clinical Fellow pt. 1
Huang Lab
Cambridge University
2016 - 2016
- Patch clamping rodent cardiomyocytes in a model of metabolic syndrome.
Intercalated BSc
Herring Lab
Oxford University
2013 - 2012
- Investigating the role of the neuropeptide Galanin in cardiac autonomics using a guinea pig Langendorff model
Industry Experience
Foundation training was in North West Thames, followed by Core Medical and Cardiology training in the East of England (run-through)
Specialty Training, Cardiology
East of England deanery
Royal Papworth Hospital, UK
current - 2017
- ST6: Royal Papworth Hospital
- ST5: Norfolk & Norwich Hospital
- ST3 & ST4: Addenbrooke’s Hospital
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Core Medical Training
East of England deanery
Addenbrooke’s Hospital
2015 - 2015
- Papworth Hospital: Cardiology
- Hinchingbrooke Hospital: Respiratory
- Addenbrooke’s Hospital: ICU
Foundation Training
NW Thames deanery
Charing Cross Hospital
2015 - 2013
- Harefield Hospital: Cardiology
- Hillingdon Hospital: A&E
- Charing Cross Hospital: Acute Medicine
Medical Elective
New York
Mount Sinai Hospital
2013 - 2013
Teaching Experience
I like education…
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Selected Data Science Writing
I regularly blog about data science and visualization on my blog LiveFreeOrDichotomize.
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Selected Press (About)
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Selected Press (By)
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Selected Publications, Posters, and Talks
Building a software package in tandem with machine learning methods research can result in both more rigorous code and more rigorous research
ENAR 2020
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2020
- Invited talk in Human Data Interaction section.
- How and why building an R package can benefit methodological research
Stochastic Block Modeling in R, Statistically rigorous clustering with rigorous code
RStudio::conf 2020
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2020
- Invited talk about new sbmR package.
- Focus on how software development and methodological research can improve both benefit when done in tandem.
PheWAS-ME: A web-app for interactive exploration of multimorbidity patterns in PheWAS
Bioinformatics
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2020
- Manuscript detailing application for the exploration of multimorbidity patterns in PheWAS analyses
- See landing page for more information.
Charge Reductions Associated with Shortening Time to Recovery in Septic Shock
Chest
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2019 - 2019
- Authored with Wesley H. Self, MD MPH; Dandan Liu, PhD; Stephan Russ, MD, MPH; Michael J. Ward, MD, PhD, MBA; Nathan I. Shapiro, MD, MPH; Todd W. Rice, MD, MSc; Matthew W. Semler, MD, MSc.
Multimorbidity Explorer | A shiny app for exploring EHR and biobank data
RStudio::conf 2019
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2019 - 2019
- Contributed Poster. Authored with Yaomin Xu.
Taking a network view of EHR and Biobank data to find explainable multivariate patterns
Vanderbilt Biostatistics Seminar Series
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2019 - 2019
- University wide seminar series.
Patient-specific risk factors independently influence survival in Myelodysplastic Syndromes in an unbiased review of EHR records
Under-Review (copy available upon request.)
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2019
- Bayesian network analysis used to find novel subgroups of patients with Myelodysplastic Syndromes (MDS).
- Analysis done using method built for my dissertation.
Patient specific comorbidities impact overall survival in myelofibrosis
Under-Review (copy available upon request.)
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2019
- Bayesian network analysis used to find robust novel subgroups of patients with given genetic mutations.
- Analysis done using method built for my dissertation.
R timelineViz: Visualizing the distribution of study events in longitudinal studies
Under-Review (copy available upon request.)
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2018 - 2018
- Authored with Alex Sunderman of the Vanderbilt Department of Epidemiology.
Continuous Classification using Deep Neural Networks
Vanderbilt Biostatistics Qualification Exam
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2017 - 2017
- Review of methods for classifying continuous data streams using neural networks
- Successfully met qualifying examination standards
Asymmetric Linkage Disequilibrium: Tools for Dissecting Multiallelic LD
Journal of Human Immunology
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2015 - 2015
- Authored with Richard Single, Vanja Paunic, Mark Albrecht, and Martin Maiers.
An Agent Based Model of Mysis Migration
International Association of Great Lakes Research Conference
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2015 - 2015
- Authored with Brian O’Malley, Sture Hansson, and Jason Stockwell.
Declines of Mysis diluviana in the Great Lakes
Journal of Great Lakes Research
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2015 - 2015
- Authored with Peter Euclide and Jason Stockwell.